Hydroderm is the best-selling anti-wrinkle serum extensively sold direct-to-consumer over the internet. Hydroderm incorporates the patented DermX^TM MegasphereTM Delivery System and was out-licensed by the company to a marketing, sales and distribution partner several years ago. Originally formulated by JRX Biotech researchers, Hydroderm has had cumulative retail sales in excess of $100 million.